http://retinoblastoma-cancer.com Just another WordPress weblog Tue, 27 May 2008 14:53:53 +0000 http://backend.userland.com/rss092 en Lalita Wadhwa1,2,3, Mary Y. Hurwitz1,2,3, Patricia Chévez-Barrios1,6 and Richard L. Hurwitz1,2,3,4,5 1 Texas Children's Cancer Center; 2 Center for Cell and Gene Therapy; Departments of 3 Pediatrics, 4 Ophthalmology, and 5 Molecular and Cellular Biology, Baylor College of Medicine; 6 Department of Pathology, The Methodist Hospital, Houston, Texas Requests for ... http://retinoblastoma-cancer.com/2008/05/27/treatment-of-invasive-retinoblastoma-in-a-murine-model-using-an-oncolytic-picornavirus/ The retinoblastoma gene (RB) was identified because of germ-line mutations that strongly predisposed infants with the mutant gene to a rare cancer of the retina. However, the RB protein turned out to be a regulator of transcription in all cells of adults. The active form of the protein represses the ... http://retinoblastoma-cancer.com/2008/05/27/retinoblastoma-gene-mutations-in-human-cancer/ Retinoblastoma Deficiency Increases Chemosensitivity in Lung Cancer William A. Zagorski1, Erik S. Knudsen2 and Michael F. Reed1,3 1 Division of Thoracic Surgery, Departments of Surgery and 2 Cell and Cancer Biology, The Vontz Center for Molecular Studies, University of Cincinnati College of Medicine and 3 Department of Surgery, Cincinnati VA Medical ... http://retinoblastoma-cancer.com/2008/05/27/retinoblastoma-cancer-4/ CY Chang, DJ Riley, EY Lee and WH Lee Center for Molecular Medicine/Institute of Biotechnology, University of Texas Health Science Center at San Antonio 78245. Models for studying the quantitative effects of RB protein in development and in tumorigenesis have been constructed. By crossing transgenic mice carrying the human Rb ... http://retinoblastoma-cancer.com/2008/05/27/quantitative-effects-of-the-retinoblastoma-gene-on-mouse-development-and-tissue-specific-tumorigenesis/ Retinoblastoma is a cancer of the retina. It is caused by a mutation in the Rb-1 protein. It occurs mostly in younger children and accounts for about 3% of the cancers occurring in children younger than 15 years. The estimated annual incidence is approximately 4 per million children. The tumor may ... http://retinoblastoma-cancer.com/2008/05/27/retinoblastoma-cancer-3/ Michael F. Reed, MD a , * , William A. Zagorski, BS a , John A. Howington, MD a , Jack T. Zilfou, PhD c , Erik S. Knudsen, PhD b a Division of Thoracic Surgery, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio b Department of Cell ... http://retinoblastoma-cancer.com/2008/05/27/inhibition-of-retinoblastoma-tumor-suppressor-activity-by-rna-interference-in-lung-cancer-lines/ Mellone N. Marchong1,2, Danian Chen1,6, Timothy W. Corson1,3, Cheong Lee1, Maria Harmandayan1, Ella Bowles1, Ning Chen5 and Brenda L. Gallie1,2,3,4,5 Divisions of Cancer Informatics and Cellular and Molecular Biology, Ontario Cancer Institute/Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada; Departments of 2 Medical Biophysics, 3 Molecular and Medical Genetics, ... http://retinoblastoma-cancer.com/2008/05/27/minimal-16q-genomic-loss-implicates-cadherin-11-in-retinoblastoma/ Nikia A. Laurie1, Jonathan K. Gray1, Jiakun Zhang1, Mark Leggas2, Mary Relling2, Merrill Egorin3, Clinton Stewart2 and Michael A. Dyer1 Authors' Affiliations: Departments of 1 Developmental Neurobiology and 2 Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee and 3 University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania Requests for reprints: ... http://retinoblastoma-cancer.com/2008/05/27/topotecan-combination-chemotherapy-in-two-new-rodent-models-of-retinoblastoma/ A Probabilistic Model for the Incidence of Retinoblastoma Alfred G. Knudson, Herbert W. Hethcote, and Barry W. Brown The incidences of some childhood cancers have been shown to fit a two-mutation hypothesis for cancer initiation. According to this hypothesis, the first mutation can be either germinal or somatic while the ... http://retinoblastoma-cancer.com/2008/05/27/mutation-and-childhood-cancer/ An Extended Follow-Up Ruth A. Kleinerman, Margaret A. Tucker, Robert E. Tarone, David H. Abramson, Johanna M. Seddon, Marilyn Stovall, Frederick P. Li, Joseph F. Fraumeni, Jr From the Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services; International Epidemiology ... http://retinoblastoma-cancer.com/2008/05/27/risk-of-new-cancers-after-radiotherapy-in-long-term-survivors-of-retinoblastoma/